⚕️ For clinical reference only. Not a substitute for professional judgment.
eGFR CKD-EPI 2021
Estimated glomerular filtration rate using the CKD-EPI 2021 race-free equation. Gold standard for CKD staging.
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Enter values
Awaiting creatinine, age, and sex.
Patient Details
years
KDIGO CKD Staging
G1: ≥90 mL/min — Normal / high
G2: 60–89 — Mildly decreased
G3a: 45–59 — Mild-moderate
G3b: 30–44 — Moderate-severe
G4: 15–29 — Severely decreased
G5: <15 — Kidney failure
G2: 60–89 — Mildly decreased
G3a: 45–59 — Mild-moderate
G3b: 30–44 — Moderate-severe
G4: 15–29 — Severely decreased
G5: <15 — Kidney failure
Clinical Notes
- Use CKD-EPI for CKD staging and nephrology referral (more accurate at higher GFR)
- Use Cockcroft-Gault for drug dosing (LMWH, DOACs, metformin, antibiotics)
- Most drug trials defined renal thresholds using CG — check individual SPC/BNF
- Inaccurate in: extremes of muscle mass, malnutrition, AKI, pregnancy
Formula (CKD-EPI 2021)
Female, Cr ≤0.7: 142 × (Cr/0.7)^-0.241 × 0.9938^Age × 1.012
Female, Cr >0.7: 142 × (Cr/0.7)^-1.200 × 0.9938^Age × 1.012
Male, Cr ≤0.9: 142 × (Cr/0.9)^-0.302 × 0.9938^Age
Male, Cr >0.9: 142 × (Cr/0.9)^-1.200 × 0.9938^Age
(Cr in mg/dL)
Female, Cr >0.7: 142 × (Cr/0.7)^-1.200 × 0.9938^Age × 1.012
Male, Cr ≤0.9: 142 × (Cr/0.9)^-0.302 × 0.9938^Age
Male, Cr >0.9: 142 × (Cr/0.9)^-1.200 × 0.9938^Age
(Cr in mg/dL)
References
- Inker LA et al. N Engl J Med. 2021. (CKD-EPI 2021, race-free)
- KDIGO CKD Guidelines 2022.
- NICE CG182 — Chronic kidney disease. Updated 2021.