⚕️ For clinical reference only. Not a substitute for professional judgment.

HOMA-IR Endocrine

Homeostatic Model Assessment of Insulin Resistance — estimates insulin resistance from fasting glucose and insulin. Used in metabolic syndrome evaluation.

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Enter fasting values

Enter fasting glucose and fasting insulin to calculate HOMA-IR.

Fasting Values (minimum 8-hour fast)

Fasting Glucose

mmol/L

Fasting Insulin

mU/L (pmol/L ÷ 6)

Formula & Interpretation

HOMA-IR = (Fasting Glucose x Fasting Insulin) / 22.5 (Glucose in mmol/L, Insulin in mU/L) <1.0: Optimal insulin sensitivity 1.0–1.9: Early insulin resistance 2.0–2.9: Significant insulin resistance >3.0: Marked insulin resistance / metabolic syndrome

When to use

Metabolic syndrome assessment alongside waist circumference, lipids, BP
Monitoring response to lifestyle intervention or metformin
PCOS — quantifying insulin resistance
Not for use in insulin-treated patients (values unreliable)